It is a condition in which smaller kidney units are damaged which results in kidney function malfunction. This is because the activity of the glomerulus is impaired by high glucose levels. Diabetic nephropathy has various symptoms including weight loss, swollen ankle or foot, dry skin, and muscle cramps. Some of the major causes of diabetic nephropathy are smoking habits, high blood pressure, and blood glucose levels. Drugs such as angiotensin-converting enzymes are used to treat one of the major causes of this condition, high blood pressure, as the first line of diabetic nephropathy treatment.